What is menopause?

Menopause is the end of female fertility, occurring 12 months after a woman’s last menstrual period.

For most women, the onset of menopause – known as perimenopause or transitional menopause – begins in their late 30s or early 40s, when their ovaries start producing less of the reproductive hormones estrogen and progesterone. On average, naturally occurring menopause usually happens by age 51.

Premature menopause can also happen at any age as the result of surgery. A total hysterectomy, which is the removal of a woman’s uterus and ovaries, can cause menopause without any transitional phase. This sudden onset typically places a higher burden of symptoms on surgically-induced menopause patients.

What are the symptoms of menopause?

The most common symptoms of menopause include:

  • Hot flashes
  • Night sweats
  • Sleep problems
  • Mood changes
  • Vaginal dryness
  • Weight gain and slowed metabolism
  • Thinning hair and dry skin

Over 10 million women in the US, approximately two-thirds of women aged 50-65, experience hot flashes due to naturally-occurring menopause. Of these, roughly half have symptoms severe enough to seek medical treatment. Hot flashes can dramatically impact the quality of life for menopausal and perimenopausal women, and may contribute to other symptoms such as sleep problems and mood changes.

What are the options for dealing with menopause symptoms?

While there is no “cure” for menopause, there are treatments for the symptoms of menopause. For those with moderate and severe hot flashes, there are two FDA approved medications: hormone therapy and a low dose version of the generic anti-depressant paroxetine.

MenoGeniX is committed to developing MNGX-100 to provide a potential alternative for women with either naturally occurring or surgically induced menopause who suffer from moderate to severe hot flashes and other vasomotor symptoms.

How is MNGX-100 different?

MNGX-100 is neither a hormone therapy nor an anti-depressant. MNGX-100 is based on a naturally occurring human protein.